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How to use peptide products effectively

December 3, 2025 by Katie Meehan Leave a Comment

Have you heard about peptides and wondered what they actually do? In simple terms, peptides are “strings of molecules called amino acids that build blocks’ of proteins,” says WebMD.

When these are applied topically, they can signal skin cells to ramp up production of skin-supporting proteins like collagen and elastin. If you’re interested in trying out peptide products, have a look at the following tips that can help you be able to understand them better and incorporate them into your skincare routine.

Consider your goals

Not all peptides are the same. There are different types formulated to target different skin concerns, such as;

Anti-aging: Some peptides often called “signal peptides” can trigger your skin to increase collagen and elastin production, which helps to smooth any fine lines and make your skin firmer.

Hydration and elasticity: Peptides can be used to help lock in moisture in the skin and reduce any dryness.

Barrier support and skin tone: Some peptides can help to restore the skin’s barrier and repair any damage.

When picking peptide skincare products, think about what your skin needs most – whether that’s hydration, plumping, or brightening – and choose those that support your goals.

Follow the golden rule of application

To help make your peptide products work efficiently, it is important to apply them at the right point in your skincare routine. The general rule with applying skincare products is by working in layers but applying products from the thinnest to the thickest consistency.

That typically means:

  1. Cleanser
  2. Toner 
  3. Serum
  4. Eye cream
  5. Moisturizer
  6. Sunscreen (Used in the morning)

For example, if you’re using a peptide serum, avoid starting your routine with layering heavier creams or oils as the first step, as this may cause the product to not absorb into the skin as well. 

Pair your peptides with other powerful ingredients

To achieve your skin goals, it is important to consider which other ingredients can pair well alongside your peptide products.

Here are a few examples of other ingredients that can be incorporated into your routine alongside peptides:

Hyaluronic acid: This is great for helping to lock moisture into your skin, whilst keeping it plump and hydrated.

Ceramides: Great for helping reinforce the skin’s barrier and retain moisture.

Polyglutamic acid: Helps to draw moisture from the atmosphere into your skin, to help keep your skin moisturized and reduce lines and wrinkles.

It is important to note that some peptides, such as copper peptides can cause skin irritation if paired with certain acids of retinoids. Before purchasing any new products and creating a new routine, it is worth speaking to a skincare professional and getting advice beforehand. They’ll be able to give you bespoke advice and guidance on different products, ensuring that they can be applied to the skin safely.

Do patch tests and introduce one product at a time

As tempting as it is to overhaul your skincare all at once, try and introduce a new product one at a time, that way you’re able to monitor how your skin responds, without the confusion of which product resulted in creating a breakout, irritation, or improvement.

Patch tests are also important to do when testing out a new skincare product. By understanding your skin’s needs and choosing the right products, you’re able to reap the benefits of peptides for the skin that look and feel the best on the skin.

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Katie Meehan is a beauty, lifestyle and fashion blogger based in London.

 

As seen on BBC Three, This Morning, The Daily Mail, The Mirror and Elle UK.

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